Abstract submission deadline extended!

The deadline for abstract submissions has been extended untill August 15th, to give you the opportunity to share your latest results. Keep those abstracts coming!

The best poster presentation will receive a travel grant for ISSCR 2015 in Stockholm.

Low-grade chromosomal mosaicism in human somatic and embryonic stem cell populations

By Jacobs K et al. (Research Group Reproduction and Genetics, Vrije Universiteit Brussel)

In this study, the genetic content of 92 individual human cells, including fibroblasts, amniocytes and embryonic stem cells (hESCs) was investigated using single-cell array-based comparative genomic hybridization (aCGH). We find that human somatic and embryonic stem cell cultures show significant fractions of cells carrying unique megabase-scale chromosomal abnormalities, forming genetic mosaics that could not have been detected by conventional cytogenetic methods. Furthermore, fluorescent in situ hybridisation reveals an increased instability of the subtelomeric regions in hESC as compared to somatic cells. This genetic heterogeneity may have an impact on experimental results and, in the case of hESC, on their potential clinical use.

Read more at: http://www.nature.com/ncomms/2014/140627/ncomms5227/full/ncomms5227.html

Role of cell–cell adhesion complexes in embryonic stem cell biology.

By Pieters T and Van Roy F (Department of Biomedical Molecular Biology, Ghent University; Inflammation Research Center, VIB)

Mouse embryonic stem cells (mESCs) grow as compact dome-shaped colonies. This is due to cell-cell adhesion complexes that are formed amongst adjoining mESCs. In this review, we focus on the roles of cell-cell adhesion molecules, including E-cadherin and beta-catenin, in the fate, maintenance and differentiation of mammalian ESCs.
 

Read more at: http://www.ncbi.nlm.nih.gov/pubmed/24931943 http://jcs.biologists.org/content/127/12/2603.long

Your article on this website!

Dear Belgian researchers,

 

Did you recently publish your work on stem cells? We would be very happy to display it on this website.

 

Just send an email to Mieke.Geens@vub.ac.be for further instructions.