Role of cell–cell adhesion complexes in embryonic stem cell biology.

By Pieters T and Van Roy F (Department of Biomedical Molecular Biology, Ghent University; Inflammation Research Center, VIB)

Mouse embryonic stem cells (mESCs) grow as compact dome-shaped colonies. This is due to cell-cell adhesion complexes that are formed amongst adjoining mESCs. In this review, we focus on the roles of cell-cell adhesion molecules, including E-cadherin and beta-catenin, in the fate, maintenance and differentiation of mammalian ESCs.

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